Open Calls for Research

Every year in the UK, up to 21,000 women are diagnosed with a gynaecological cancer, and 22 women die from these conditions each day. Although the five gynaecological cancers: womb, ovarian, cervical, vulval and vaginal cancer account for 6% of all new cancer diagnoses, and 5% of all cancer related deaths, awareness of these diseases remains low. The Eve Appeal is determined to change this to a future where everyone is aware of, fewer women develop and more women survive gynaecological cancers.

Research supported by The Eve Appeal is wholly focused on developing effective methods of risk prediction, prevention, the better diagnosis, and early detection of all gynaecological cancers. Our ultimate aim is to develop more systematic and comprehensive screening for this group of cancers and significantly improve patient mortality.

Early Diagnosis and Prevention of Vulval Cancer

Introduction and Rationale:

The Eve Appeal has received private donations from people who have been personally affected by vulval cancer who wish to support research restricted to its prevention and early diagnosis. The charity is now seeking innovative applications from the research community for work in this field; to advance and improve the early diagnosis and prevention of Vulval Cancer.

The Eve Appeal can commit up to £30k for research into the early diagnosis or prevention of vulval cancer. We anticipate awarding one or two pilot or proof of concept projects with results from the work leading to further grant applications to other funding bodies.

The deadline for applications is 4pm Thursday 10th June 2021

The Challenge:

Vulval cancer is a relatively rare cancer with around 1,300 cases diagnosed in the UK each year. It is more common in older women, with on average each year around 45% of new cases being in women aged 75 and over. Surgery to remove the cancer is the standard course of treatment. Surgery can range from a small excision to full vulvectomy – removing a woman’s vulva, her inner and outer labia, and possibly her clitoris. This invasive surgery can have a devastating impact on a women’s quality of life, affecting her body image and sex life.

We know that avoiding certain risk factors and having pre-cancerous conditions treated early can reduce a woman’s chance of developing vulval cancer. But with very little vulval cancer prevention research happening in the UK, we have now set up this new research award, supported by donations from people who have been personally affected by this devastating disease.

We want to invest in prevention and are particularly interested in research which aims to understand if we can identify factors that put women at risk of developing vulval cancer.  This could be through small-scale sample collection, a focus on HPV or other identified risk factors, or investigation of the immune response.

It is a rare cancer that needs to be diagnosed earlier, to save women’s lives and avoid very invasive and life-changing treatment.

Outputs from the research studies:

  • Annual reports detailing the progress made through the project to be submitted to The Eve Appeal.
  • A final report submitted to The Eve Appeal describing the work undertaken and how it has addressed one or more of the challenges identified above.

Outcomes from the research studies:

  • It is expected that the successful awardees will be in a stronger position to apply for longer-term funding from funders such as the MRC, CRUK, Wellcome Trust, industry, EU, and other relevant funding bodies.
  • Through close working with The Eve Appeal, to help raise public comprehension of vulval cancer and so provide the basis for better understanding of gynaecological cancer conditions.
  • This area of research could open new research avenues for all gynaecological cancer conditions.

Application and assessment process:

Who can apply and what you can apply for:

This call is open to individual researchers or teams affiliated to a university, hospital, or other recognised research institution in the UK. Though the applications should have a UK focus, collaborations with international partners are encouraged.

The Eve Appeal is keen to increase the numbers of researchers working in the field of gynaecological cancers with the aim of improving opportunities for new breakthroughs and the transfer of knowledge and findings from other cancer fields. Evidence from other disease areas suggests there may be similarities across diseases in risk factors and mechanistic features, with the potential to drive forward our understanding of the causes of individual cancers by encouraging research that works across or learns from other cancer conditions. This is particularly true of vulval cancer, where the Vulval Cancer NCRI-CSG has noted that vulval cancer shares some biological features with anal cancer.

The Eve Appeal can commit up to £30k for research into the early diagnosis or prevention of vulval cancer. We anticipate awarding one or two pilot or proof of concept projects with results from the work leading to further grant applications to other funding bodies.  Awards will be for up to a maximum of £30,000 for up to 24 months with an expected start-date of November 2021.

Research involving patients, service users, care professionals or volunteers, or their organs, tissue or data must obtain Research Ethics Committee (REC) approval before any work can start. For any pre-clinical studies using animal models, The Eve Appeal is fully committed to the 3Rs principles (Replace, Reduce, Refine) and all funded research should abide by rules set out by the Home Office. Under this system, animals can only be used when there is no alternative.

Assessment:

This is a single stage application process.

Applications will undergo expert peer review. Assessment by lay people may also form part of the review process, as such, applicants should carefully consider the use of non-scientific language in the application form and in particular within the lay summary.

Depending on the number of applications, The Eve Appeal may undertake a triage stage based on reviewer feedback prior to the final scientific panel meeting. A panel of scientific experts will recommend awards to the Trustees of The Eve Appeal Charity.

The criteria used to assess applications include:

  • Relevance to the understanding of risk prediction and/or prevention, or the development of early and better diagnosis of vulval cancer.
  • Involvement of people with gynaecological conditions in the proposed research.
  • Clear description and justification of how the project methodology will address the proposed study design and deliver the required outcomes.
  • Applicants’ track record and ability to deliver the proposed research, and facilities to conduct the proposed research
  • Where relevant the strength and make-up of the research team.
  • Feasibility, the potential to deliver the stated outcomes within the timescales and budget
  • Value for money

Patient and Public Involvement

We believe that involving people affected by medical conditions strengthens the quality and relevance of medical research. We encourage applicants to consider how the quality, feasibility or practicality of their proposal could be improved by involving people affected by gynaecological cancer in its development or oversight.

Contact details and how to apply:

To submit a proposal on one of these topics, download the application form from The Eve Appeal website.

Applications should be submitted to research@eveappeal.org.uk

Applications will be acknowledged, if you have not received an acknowledgement within three working days, please email helen.hurman@eveappeal.org.uk 

Deadline for application 4pm, Thursday 10th June 2021

Planned notification of award: September 2021

Planned project start date: November 2021

Enquiries

Please contact email: research@eveappeal.org.uk

Funder information

The Eve Appeal is a registered charity in England and Wales (No. 1091708) and in Scotland (No. SC042612). A company limited by guarantee (England) No. 4370087. Registered office: 15B Berghem Mews, Blythe Road, London W14 0HN.

 

Small Grant Awards

Deadlines for applications: June 3rd; July 22nd: September 9th

Introduction and Rationale: 

The Eve Appeal is launching its Small Grant Awards, seeking innovative applications from the UK research community for the early development of research ideas that could lead to new research proposals focused on the prevention of gynaecological cancers. We envisage that the awards will support small scale projects such as: feasibility studies, data analysis, surveys, patient engagement, and focus groups.

Application and assessment process:

Who can apply and what you can apply for:

Small Grant Awards are open to individual researchers or teams affiliated to a university, hospital, or other recognised research institution in the UK. The Principal Applicant must hold a permanent post at either a UK Higher Education Institution or within the NHS.

The Eve Appeal is keen to increase the numbers of researchers working in the field of gynaecological cancers with the aim of improving the chances of new breakthroughs and the potential transfer of knowledge and findings from other cancer fields.

This is an open call, with awards of up to £2500 for projects of up to 18months.

Though the applications should have a UK focus, collaborations with international partners are eligible.

Institutional Approval:

Research involving patients, service users, care professionals or volunteers, or their organs, tissue or data must obtain Research Ethics Committee (REC) approval before any work can start. For any pre-clinical studies using animal models, The Eve Appeal is fully committed to the 3Rs principles (Replace, Reduce, Refine) and all funded research should abide by rules set out by the Home Office. Under this system, animals can only be used when there is no alternative.

The application must be approved within the host institution by both the Principal Applicant and the Head of Department or their equivalent.  The application form must also be signed by the Finance/Administrative Officer on behalf of the institution. Those signing must have the authority to sign on behalf of the institution. We will accept electronic signatures.

Assessment:

This is a single stage application process.

Applications will be reviewed by two members the Research Advisory Committee (RAC) or where appropriate an invited expert.  Assessment by lay people may also form part of the review process, as such, applicants should carefully consider the use of non-scientific language in the application.

The RAC will recommend funding awards to the Trustees of The Eve Appeal Charity.

The criteria used to assess applications include:

  • Relevance to the understanding of prevention, or the development of early and better diagnosis of gynaecological cancers.
  • Involvement of people with gynaecological conditions in the proposed research.
  • Clear description and justification of how the project methodology will deliver the stated outcomes.
  • Applicants’ track record and ability to deliver the proposed research, and the facilities to conduct the proposed research.
  • Feasibility, the potential to deliver the stated outcomes within the timescales and budget.
  • Value for money.

Patient and Public Involvement:

We believe that involving people affected by medical conditions strengthens the quality and relevance of medical research. We encourage applicants to consider how the quality, feasibility or practicality of their proposal could be improved by involving people affected by gynaecological cancer in its development and oversight.

Contact details and how to apply:

To submit a proposal, download the small grants application form from The Eve Appeal website.

Completed applications should be submitted to research@eveappeal.org.uk

This is an open call for applications for the next 9 months to October 2021. The Eve Appeal reserves the right to close this call for applications if the small grants fund is fully committed before this date. Applications will be reviewed after three deadlines 3rd June, 22 July, and 9th September.

Applicants will receive an acknowledgement of your application within five working days of submission. If you have not received an acknowledgement after 5 working days, please contact: helen.hurman@eveappeal.org.uk

Funder information

The Eve Appeal is a registered charity in England and Wales (No. 1091708) and in Scotland (No. SC042612). A company limited by guarantee (England) No. 4370087. Registered office: 15B Berghem Mews, Blythe Road, London W14 0HN.