Research news: Second Eve Fellowship to try detect ovarian cancer in the early stages 

This fellowship aims to create a new blood test to detect ovarian cancer at its earliest stages when it is most treatable. 

  • November 21, 2024
  • The Eve Appeal
We are thrilled to announce that in partnership with North West Cancer Research, we have awarded our second Fellowship to Dr Neil Ryan, Chief Scientific Officer, Clinical Lecturer and Subspecialty Trainee in Gynaecology Oncology from the University of Edinburgh.

Finding ovarian cancer early is critical to helping those diagnosed live longer and have more time with their loved ones. Currently, most cases are diagnosed too late, leading to poorer outcomes. Neil’s research hopes to change this. He plans to look for proteins that are signs of ovarian cancer that can be used as a blood test to pick it up in the earliest stages.  

We are incredibly excited to fund Neil’s work. Ovarian cancer remains one of the hardest gynaecological cancers to detect early, and this research could make a critical difference. Neil has already made significant contributions to The Eve Appeal’s mission, and his passion and commitment make him a valued asset to our research efforts. – Athena Lamnisos, Eve CEO

There is currently no national screening test for ovarian cancer. If someone goes to the doctor with symptoms that could be caused by ovarian cancer, a blood test will be done to look for CA125, which can be elevated in ovarian cancers. But this test isn’t very specific as high levels of CA125 can be caused by other issues as well as cancer. The level of CA125 can also be normal even when someone does have ovarian cancer.  

Because of this, the CA125 blood test picks up just 5-6 in every 10 cases of early ovarian cancer in postmenopausal women (who haven’t had a period for 12 months or more). Sadly, most ovarian cancers are found at a late stage, and just three in 10 of these women live for five years of more. 

Treatments for ovarian cancer have come a long way in the last 20 years and late diagnosis is the biggest hurdle we face in helping more people survive their diagnosis. Neil hopes that the proteins he finds could lead to larger studies looking in to whether they could be used as a screening test for ovarian cancer.  

He will look at blood samples from women with early ovarian cancers, healthy women, and women with non-cancerous cysts. Neil will try find the key proteins in the blood that show up in those with early-stage ovarian cancers. His goal is to create a test that could be widely used by the NHS.

This Fellowship is part of North West Cancer Research and The Eve Appeal’s commitment to investing in the future, and the brightest minds in gynaecological cancer research. We hope that Neil’s work on ovarian cancer will lead to improvements in early detection, and ultimately, survival rates for women. – Alastair Richards, CEO of North West Cancer Research
The British Gynaecological Cancer Society is delighted to support The Eve Appeal’s fellowship program, which champions early career researchers like Dr Neil Ryan. This initiative enables rising stars in our field to pioneer life-changing advancements in gynaecological oncology, especially in areas as vital as early detection for ovarian cancer. We look forward to seeing the progress and impact Neil’s research will have for women’s cancer care in the UK and beyond. – Dr Stephen Dobbs, President of the British Gynaecological Cancer Society

He will be working with two patient advisory groups, bringing in the thoughts of women with experience of ovarian cancer.

Being awarded The Eve Appeal and North West Cancer Research Fellowship is not only a massive honour and privilege, but it also represents a pivotal moment in my career. Working alongside these transformative charities has been a long-held ambition, as their commitment to funding research that has a tangible impact on patient care is perfectly aligned with my dedication to improving outcomes for women with gynaecological cancer. – Dr Neil Ryan

A huge thank you for all of your support for making this Fellowship possible.

I am so grateful to all the donors who have made this funding possible and I will work tirelessly to ensure their support translates into meaningful results for ovarian cancer care. – Dr Neil Ryan

More information and advice

We have lots more information and advice about on our research and ovarian cancer. You can also contact our Ask Eve nurses for free to chat about any worries or questions.

By supporting The Eve Appeal, you can play a vital role in driving forward research into gynae cancers.

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