What is Cervical Cancer?

Cervical cancer is cancer of the cervix (also known as the neck of the womb) which connects a woman's womb and her vagina.
Cervical cancer can affect women of all ages but affects women primarily 30 - 45 years of age. It is very rare in women under 25 years of age. In the UK we have a very successful cervical screening programme which is estimated to save over 4,000 lives each year.

How does it develop?

Nearly all squamous cervical cancers are caused by a common sexually transmitted infection called human papillomavirus (HPV). This is why the UK government is vaccinating girls at an early age before they are potentially exposed to the HPV virus (i.e. before they experience sexual activity). Sex is a normal, healthy activity, and the wearing of condoms is advised to protect both partners from unwanted pregnancies and reduce exposure to HPV, as well as other transmissible conditions.

Most women will contract HPV at some stage during their life, but this usually clears up on its own without the need for any treatment.

HPV is a group of viruses, of which there are more than 100 different types. It is spread during sexual intercourse and other types of sexual activity (such as skin-to-skin contact of the genital areas).

If the body is unable to clear the virus, there is a risk of abnormal cells developing, which could become cancerous over time.

Cervical cancer can affect women of all ages, but is most common in women aged 30 – 45; although in rare cases can occur in women under 25.

Key signs of cervical cancer - symptoms

The symptoms of cervical cancer aren’t always obvious, it may not cause any symptoms at all until it’s reached an advanced stage. Some women do not experience any signs of cervical cancer at all.

This is why it’s very important that you attend all of your cervical screening appointments.

Unusual bleeding
In most cases, vaginal bleeding is the first of the cervical cancer symptoms to be noticeable. It often occurs after having sex.

Bleeding at any other time, other than your expected monthly period, is also considered unusual, this also includes bleeding after the menopause.

Other symptoms
Other signs of cervical cancer may include pain and discomfort during sex and an unpleasant smelling vaginal discharge.

However, the vast majority of women with the cervical cancer symptoms listed above do not have cervical cancer, and are far more likely to be experiencing other conditions, such as infections.

Risk Factors

The fact that HPV infection is very common but cervical cancer is relatively uncommon suggests that only a very small proportion of women are vulnerable to the effects of an HPV infection. There appear to be additional risk factors that affect a woman’s chance of developing cancer of the cervix. These include:

  • Smoking – women who smoke are twice as likely to develop cervical cancer as women who don’t; this may be caused by the harmful effects of chemicals found in tobacco on the cells of the cervix.
  • Immunosuppression drugs – women who are on Immunosuppression drugs (reduces the strength of the body’s immune system) can be at increased risk of developing cervical cancer.

How is it diagnosed?

You’ll be referred to a gynaecologist if the results of your cervical screening test suggest that there are abnormalities in the cells of your cervix. However, in most cases, the abnormalities do not mean you have cancer of the cervix.

You may also be referred to a gynaecologist if you have abnormal vaginal bleeding, or other worrying cervical cancer symptoms, such as if your GP has noticed a growth inside your cervix during an examination.

Additionally, your gynaecologist or a specialist nurse may perform a colposcopy – an examination to look for abnormalities in your cervix. During a colposcopy, a small microscope with a light source at the end (colposcope) is used. As well as examining your cervix, your gynaecologist may remove a small tissue sample (biopsy) so that it can be checked under a microscope for cancerous cells.

Cervical Cancer Treatment

Treatment for cervical cancer depends on the size of the cancer cell collection and the shape of it.

The prospect of a complete cure is good for cervical cancer diagnosed at an early stage, this decreases the further the cancer has grown into or around the cervix.

Removing abnormal cells
If your screening results show that you don’t have cancer of the cervix, but there are biological changes that could turn cancerous in the future, a number of treatment options are available. These include:

  • Large loop excision of the transformation zone (LLETZ) – the abnormal cells are removed under local anaesthetic.
  • Cone biopsy – the area of abnormal tissue, in the shape of a cone, is removed during surgery

Surgery
There are three main types of surgery for cervical cancer:

  • Radical trachelectomy – the cervix, surrounding tissue and the upper part of the vagina are removed, but the body of the womb is left in place. This cervical cancer treatment is only a suitable if the diagnosis is made at a very early stage. In addition lymph nodes that are related to this area are sampled to check for microscopic spread.
  • Hysterectomy – the cervix and womb are removed, which is recommended for early cervical cancer, and in some cases a course of radiotherapy may follow to help prevent the cancer coming back.
  • After Pelvic Exoneration – a major operation that’s usually only recommended when cervical cancer returns what was thought to be a previously successful course of treatment, in which the cervix, vagina, womb, bladder, ovaries, fallopian tubes and rectum are removed.

Radiotherapy is also considered as part of cervical cancer treatment; an alternative to surgery it has a similar cure rate and has the advantage of avoiding an operation when the cancer is close to the bladder or colon.

Further information and support

For further information about cervical cancer, treatment options and support, please visit Jo’s Cervical Cancer Trust.