Risks associated with BRCA gene mutations

What are the risks associated with carrying a faulty BRCA gene?

BRCA1 and BRCA2

Women who carry a BRCA mutation are at increased risk of developing breast cancer, ovarian cancer and pancreatic cancer.

Men who carry a BRCA mutation are at increased risk of developing breast cancer, prostate cancer and pancreatic cancer. Risks in men are mainly linked to BRCA2.

There may be an increased risk of developing melanoma (a form of skin cancer) if you carry a BRCA2 mutation, however evidence to support this is limited and more research needs to be done in this area.

The risks vary depending on a number of factors, such as your specific mutation, age and family history. Your genetics team or cancer clinician will be able to discuss your risk with you in detail and talk you through the options available to you.

When you are given your genetic test results, your risks may be presented as a percentage lifetime risk – it is important to note that your risk will change at different periods and is not static throughout your lifetime.

The-Eve-Appeal-BRCA-Lifetime-Risk
Lifetime Risk of Breast/Ovarian Cancer with BRCA1 and BRCA2 gene mutations